Hypercalcemia, Hypocalcemia and the Parathyroid Glands

The thyroid gland (orange) and the parathyroid glands as viewed from the back of the body; the barred structure in the middle of the diagram is the back of the trachea, or windpipe
The thyroid gland (orange) and the parathyroid glands as viewed from the back of the body; the barred structure in the middle of the diagram is the back of the trachea, or windpipe | Source

The Importance of Calcium

Calcium is a vital chemical in our bodies and has many functions. It's needed for muscle contraction (including the contraction of the heart muscle), nerve and brain function, bone formation, blood clotting and many other jobs. Although an adequate amount of calcium in the blood is essential for our health, too much can be dangerous.

The parathyroid glands are small structures that are located in the neck. Their job is to make parathyroid hormone, also known as PTH or parathormone. PTH stimulates body processes that increase the amount of calcium in the blood.

If too much PTH is made, hypercalcemia develops. Hypercalcemia is a disorder in which the blood contains excess calcium. On the other hand, if too little PTH is made, hypocalcemia develops. In hypocalcemia, the blood doesn't contain enough calcium. Either condition may range in severity from a minor problem to a serious disease. Luckily, treatments are available for both disorders.

Richard Owen (1804 - 1892) discovered the parathyroid glands by dissecting a dead rhinoceros.
Richard Owen (1804 - 1892) discovered the parathyroid glands by dissecting a dead rhinoceros. | Source

The Parathyroid Glands

The four parathyroid glands are usually found behind the thyroid gland, which is also known as the thyroid. Occasionally, one or more of the glands may be found inside the thyroid gland, in the neck above the thyroid or occasionally even in the chest behind the sternum (breastbone).

Although the parathyroid glands are located next to the thyroid, they are structurally and functionally distinct from it. It wasn't until 1850 that the glands were considered to be separate entities, however. Sir Richard Owen is credited with their discovery.

Owen was an anatomist and paleontologist. He noticed the presence of the parathyroid glands when he dissected a dead Indian rhinoceros from the London Zoo, although at this point they had no name and their function was unknown. Richard Owen is also famous for his creation of the name "dinosaur" from the Greek words for "terrible lizard", and for his criticism of Charles Darwin's theory of evolution by natural selection.

Parathyroid Gland Discovery in Humans

Ivar Viktor Sandström was a Swedish medical student. He discovered the parathyroid glands in humans in 1880 and gave them their name. The function of the glands was established in the early 1900s after a series of experiments by different scientists.

The Parathyroid Glands and Disease

Functions of Parathyroid Hormone

A molecule of parathyroid hormone is a protein made of 84 amino acids. The hormone does its job by affecting the bones, the intestine and the kidneys. In a healthy body, the level of PTH is adjusted to keep the calcium level in the blood constant. There are factors that can hinder this control of the calcium level, however.

  • Parathyroid hormone stimulates the activity of osteoclasts, which are cells in bone that break the bone down. The process releases calcium into the bloodstream. (Other cells called osteoblasts build bone.)
  • PTH increases the absorption of calcium from the digested food in the small intestine by promoting the formation of the active form of vitamin D. The vitamin helps calcium to pass from the small intestine into the bloodstream.
  • PTH stimulates calcium reabsorption in the kidneys so that the calcium isn't eliminated from the body in the urine. In the kidneys, calcium (which exists as calcium ions in the body) is filtered out of the blood into the kidney tubules. Some is then reabsorbed further along in the kidney tubules, passing from the tubules into the surrounding blood vessels. Any calcium that stays in the tubules is excreted in the urine.

Parathyroid hormone also decreases the reabsorption of phosphorus in the kidney, reducing its level in the blood. Phosphorus travels through the blood in the form of phosphate.

A kidney contains tubules called nephrons.
A kidney contains tubules called nephrons. | Source

Meaning of Hypo and Hyper

In science, the prefix 'hypo" is used to refer to something that is too low or insufficient, as in hypocalcemia. On the other hand, the prefix "hyper" refers to something that is too high or excessive, as in hypercalcemia.

Primary Hyperparathyroidism and Hypercalcemia

The most common cause of hypercalcemia is primary hyperparathyroidism, a condition arising from a problem in a parathyroid gland. The problem is usually a tumor, or adenoma. The tumor is generally benign, which means that it doesn't spread through the body.

When a parathyroid gland enlarges, the additional cells produce extra PTH. This results in an elevated calcium level in the blood. The bones may weaken as PTH stimulates them to release calcium. Extra calcium may travel through the kidneys, producing kidney stones. Fortunately, a tumor on a parathyroid gland can generally be removed by surgery.

Primary Hyperparathyroidism Animation

Other Causes of Hypercalcemia

A benign tumor (or tumors) is usually responsible for hypercalcemia, but there are many other possible causes.

  • Some prescribed medications can cause the condition.
  • Taking large amounts of calcium or vitamin D supplements for a long time may also increase the calcium level in the blood.
  • Dehydration can produce a temporary increase in the concentration of calcium in the bloodstream.
  • Lying immobilized in bed for a long period of time may cause hypercalcemia.
  • Kidney or adrenal gland problems can produce hypercalcemia, and so can problems with other hormones in the body besides PTH.
  • Some types of inflammation or cancer can cause the disorder as well.

In a rare inherited condition (familial hypocalciuric hypercalcemia), the gene that codes for a calcium-sensing receptor doesn't work properly. This receptor is present in the parathyroid glands as well as in other parts of the body. Without a properly functioning receptor, the parathyroid gland isn't "told" that the blood contains calcium, so it continues to make PTH. This raises the level of calcium in the blood.

Dehydration can cause temporary hypercalcemia.
Dehydration can cause temporary hypercalcemia. | Source

Possible Symptoms of Hypercalcemia

The following symptoms may indicate the presence of hypercalcemia, although they can also indicate other health problems. Some people who have the disorder have no symptoms, especially when the condition is mild.

  • Bone problems: pain, curvature of bones, fractures
  • Muscle problems: weakness, twitches
  • Gastrointestinal tract problems: pain, nausea, vomiting, loss of appetite, constipation
  • Kidney problems: back pain, thirst, frequent urination
  • Nervous system problems: memory loss, confusion, depression, fatigue


Since there are many different causes of hypercalcemia, treatment varies. Anyone with symptoms that might indicate the presence of the disorder (or of hypocalcemia) should visit a doctor for a diagnosis and treatment plan.

Multiple fractures; hypercalcemia may lead to broken bones
Multiple fractures; hypercalcemia may lead to broken bones | Source

Hypoparathyroidism and Hypocalcemia

Hypoparathyroidism is a rare disorder in which the parathyroid glands are inactive or underactive. Two possible causes of the disorder are the removal of the parathyroid glands during thyroid gland surgery and injury to the glands during neck surgery. An autoimmune disease that attacks the glands may also cause hypoparathyroidism.

Low magnesium levels may prevent enough PTH from being made. In addition, there are inherited conditions that prevent the production of PTH. One of these conditions is DiGeorge syndrome. A person with this condition may be born with no parathyroid glands.

When parathyroid glands are missing or damaged, either no PTH is produced or the amount that is made is insufficient. The hormone problem causes the calcium level in the blood to fall. It also causes the level of phosphorus in the blood to rise, since phosphorus reabsorption in the kidney is no longer being inhibited.

Occasionally the parathyroid glands are working correctly but the bones or kidneys fail to respond to PTH, resulting in a condition called pseudohypoparathyroidism. This may lead to hypocalcemia.

Hypoparathyroidism Development and Symptoms

Possible Symptoms of Hypocalcemia

As is the case for hypercalcemia, having one or more of the following symptoms could indicate the presence of another health problem instead of hypocalcemia. If someone has unexplained symptoms that worry them they should visit a doctor.

  • tingling in the lips, fingers or toes
  • muscle aches or cramps
  • muscle twitches
  • weakness and fatigue
  • dry skin
  • brittle nails
  • hair loss
  • headaches
  • anxiety
  • depression
  • memory loss

Complications of hypocalcemia include heart, kidney or teeth problems, the development of cataracts or the formation of calcium deposits in the brain.

A headache and fatigue are possible symptoms of hypocalcemia (and of many other disorders as well).
A headache and fatigue are possible symptoms of hypocalcemia (and of many other disorders as well). | Source

Treatment of Hypoglycemia

Calcium and vitamin D supplements in appropriate doses are usually prescribed for hypocalcemia caused by hypoparathyroidism. Doctors may also prescribe other medications to raise the blood calcium level. In addition, a diet that is high in calcium and low in phosphorus may be recommended.

A patient may have to take supplements and follow a special diet for the rest of his or her life, but this routine should remove symptoms and prevent complications of the disease. As in hypercalcemia, the problems created by hypocalcemia and the patient's quality of life can very often be improved by following appropriate medical treatment.

References and Further Reading

Hypercalcemia Information from the National Institutes of Health

Hypocalcemia Information from the Merck Manual

© 2012 Linda Crampton

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Comments 10 comments

billybuc profile image

billybuc 3 years ago from Olympia, WA

Just another reason why I love HP...I learn the most interesting stuff in hubs like this one. Thank you for the education, and Happy New Year to you.

AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

Thank you so much for the comment, Bill. Happy New Year to you too!

RTalloni profile image

RTalloni 3 years ago from the short journey

Thanks for an interesting look at the parathyroid gland and these disorders that can occur. Being informed is being prepared in case we need the info or in case we need to share info! I'll be linking this to my hub on Tirosint, a thyroid medication, if you have no objection.

AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

Thank you very much for the comment, RTalloni. I certainly don't object to your linking this hub to your interesting hub about Tirosint. Thanks for the request.

aviannovice profile image

aviannovice 3 years ago from Stillwater, OK

This is wonderful material. Thanks for enlightening me with all the medical material. As usual, another piece well done.

AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

Thank you very much, Deb. I appreciate the comment!

Eiddwen profile image

Eiddwen 3 years ago from Wales

Interesting and so very useful to many I am sure. I wish you a wonderful 2013 my friend and here's to so many more hubs for us both to share on here too.

Take care


AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

Thank you for the visit and the comment, Eddy. I hope you have a wonderful 2013 too!

drbj profile image

drbj 3 years ago from south Florida

What an awesomely complete examination of the parathyroid glands, Alicia. Henry Gray who wrote 'Gray's Anatomy,' could have taken medical textbook writing lessons from you, m'dear. Outstanding and voted Up! Happy New Year, too.

AliciaC profile image

AliciaC 3 years ago from British Columbia, Canada Author

Thank you for such a wonderful comment, drbj!! I appreciate both the comment and the vote. Happy New Year to you, too!

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