How to Reduce the Side Effects of Wysolone (Steroids)

How to Reduce Side Effects of Wysolone
How to Reduce Side Effects of Wysolone

Why Doctors Prescribe Wysolone

Wysolone, also known as Prednisolone, is a drug widely used for immune suppression in the case of chronic allergic conditions and inflammatory diseases like rheumatoid arthritis, uvietis, asthma, autoimmune hepatitis, and Bell's palsy. It is also commonly used by opthamologists for the treatment of allergic and inflammatory conditions of the uvea, iris, conjuctiva, and optic nerves of the eyes. This medicine is also commonly prescribed to patients whose immune systems attack their own bodies because of lupus and other autoimmune diseases.

Distribution in the Body

It is well absorbed if taken orally and binds to proteins, distributing quickly throughout the body. Wysolone does pass through the placenta and also penetrates breast milk, so it is not recommended to take this medication while pregnant.


Wysolone is discharged through urine as conjugated and free metabolites. It has a one to two hour eradication half-life, meaning it takes one to two hours for half the quantity of the drug to be fully metabolized by the body.

Increased thirst and appetite are both common side effects.
Increased thirst and appetite are both common side effects.

Wysolone Side Effects

  1. Cataracts and glaucoma
  2. Peptic ulceration
  3. Slow growing rate
  4. Increase in appetite, leading to rapid weight gain
  5. Swelling of cheeks
  6. Black stool
  7. Increase in thirst
  8. Fractures and osteoporosis (Some doctors advise calcium tablets with long term use.)

You can reduce weight gain by walking twice a day.
You can reduce weight gain by walking twice a day.

How to Reduce Side Effects

Regular Testing and Doctor Visits

If you are taking this medication long term, your doctor will ask you for regular blood tests in order to keep track of and reduce side effects. These tests will include:

  • SGPT and SGOT (Tests for liver health)
  • TLC-DLC (A test for white blood cell count to check immune function)
  • HB (hemoglobin, checks oxygen in the blood)
  • Platelet count
  • R.F.T. (Checks kidney function)


  • You can reduce or maintain your weight to some extent by taking a brisk walk for 15- 30 minutes in the morning and evening.
  • Short exercises and stretching can also be beneficial to stimulate muscles and maintain your growth rate.

A diet full of fruits and leafy green vegetables will help with immune and liver function.
A diet full of fruits and leafy green vegetables will help with immune and liver function.


You should take a balanced diet, including proper nutrition. Your diet should contain:

  • Plenty of green leafy vegetables such as spinach, kale, and broccoli.
  • Fruits like red apples, bananas, grapes, and citrus fruits to maintain your natural immunity.


Before taking any medicine, make sure to consult your doctor. Some supplements that can help include:

  • Folic acid
  • Calcium
  • Liv.52 (a Himalayan product that is good for increasing the efficiency of the liver)

Make sure to take wysolone with plenty of water
Make sure to take wysolone with plenty of water

Comments 55 comments

Debal 3 years ago

Excellent article...thanks

rimjh 3 years ago


Madhur 3 years ago

Very informative article thanks

sunderaraman 3 years ago

My wi9fe has asked to put this tablet for 5 days, shall i use it, please advise..

j.chauhan 2 years ago

there is no long period it may be taken ?

poornima arora 2 years ago

I want to know the dose like 60mg for 3 weeks,50mg for 3weeks,40mg 3weeks,30mg 3weeks,20mg 3weeks,10mg 3weeks n 10mg may continue as the doctor said at present. I hav rheumatoid arthritis, parotide glands swalling almost after 20to 25days, swelling on fingers,feet n face,fewer in the mornig 100.1 n feeling of fewer all the time, dry throat in night, itching eyes n dry medicines r - c. neuobion forte od, t wysolone mentioned abov, t folitverx 25mg (wednesday), t folite 5mg od except Wednesday,t osteophos once a week75mg*3monthson Saturday after taking medicine do not sleep for 1 hour or lie down, t pigocarpine 5mg tds, c avtrin bd* 3months, t calcerrol60ic once a week*6months, genteel ointment b/e hs, refresh tears e/d after every 4 hrs

Suman Pande 2 years ago

Doctor has prescribed me Wysolone-10 for my Rhumatologic problem with other medicines. Because it's a steorid how long should i take this pl mention. I am gaining weight in cheeks . Should I take spinach, mushrooms etc because otherwise they are rich source of proteins causing Uric acid ( which increases pain)

I am taking this medicine 1 tablet daily since past 3 months.

Please clear my doubts & advise me accordingly.


KALAIVANAN 2 years ago

my mother suffered by idiopathic thrombocytopheniya, she got treatment and they prescribed wysolone 10mg for past 2 months first they given 3 tablets per day , now they decreased 3 to 1. she got side effects like swelling of face, neck ,stomach , so please suggest me further what to do, reply me to my mail

masterpal profile image

masterpal 2 years ago from BATALA Author

@ poornima arora for rheumatoid arthritis persons doctors always prefer you to take immunosuppression like wysolone, azoran 50 , methotrexate , sazo 500, and i will advise you to take the treatment very carefully! and Must follow the good doctor ! this is not a normal disease as you know it is chronic.

rekha 2 years ago

Wysolon is finish your body slowly

manjit 2 years ago

much desired guidelines

poornima 2 years ago

as I hav been advice that I hav a cronic disease I m undergoing treatment in AIIMSdelhi n on aaims doctor advice I m taking medicine. idont know the doctor is good or bad because he is a doctor of aiims delhi so naturally I consider him to be good advice I can giv u the full details of the test conducted disease identified n the treatment I m undergoing. I m strictly following every instruction given by the doctor and taking care of my diet , exercise n timings of taking medicine etc. I m aware of the side effects mentioned for wysolone steroids. but still I m ready to follow evry thing if truly advised. ultimately patient is always depending on his/her doctor n he is spl. like god.

p ASHOK KUMAR 2 years ago

MY wife is using wysolone- 5 mg, HSBS tables since 1 year. now she is suffering muscle pain, headach, stomach pain and not taking proper food how to reduce above problems please advide .. disease name reynauld arthis my mail ID polukaashokkumar@

sheetal jain 2 years ago

I have taken 50 mg wysolone for five days. Now my whole was swelled in twenty days i gain seven kgs wait.i was taken this tablet suffer for uvities

Saloni sharma 2 years ago

Hey I m a patient of sle nd I have been suffering from this problem since last 7 yrs. My treatment is going now in Chandhigarh PGI. I m fro

m Himachal distt. Bilaspur nd I m in 12th standard . I am a student of medical nd my aim is to become a doctor. When this problem came doctor advice me to take high dose 60mg nd I see that my whole body was swelled out that make me very tens . I will advice you to take regular treatment nd carefull preventions bcz PREVENTION IS BETTER THAN CURE. And also do regular yoga which keep your body fit nd never lose your confidense nd make your strong will power to face all difficult problems.

Banumathi 2 years ago

i m Nephrotic Syndrome patient for last 5 years . due to Wysoloen i affected with glucoma, and i have done my Hip Replacement and infection in stomach. Due to this i have done 3 surgeries . so pls careful while taking wysolone. reducing the dose will be best to reduce the side effects

prasahant 2 years ago

I am 22 year old, m having lung fibrosis, m taking wysolone-10 since last two years, now , i feeling weak. Please how can i reduce? m completely depneded, it will be harmful if i will cntinue in lifetime, is there any alternative is possible?

bhushan bhola 2 years ago

my wife also take wysolone for three months daily .but now she feeling not better without wysolone 5mg. she feel completely depended on this medicine.face to problem. plz help to avoid

Ramya 2 years ago

Hi I'm with RA for 10 years. And taking wysolone 5mg for 10 years with other medicines. And i'm going for checkup regularly and taking blood test as well. Now i'm going to be married in a month. I'm really worried about my pregnancy and baby. I really want to know my disease and in taken of steroids will affect my baby. Please help me to know it.

Mrs trivedi 2 years ago

Is wysolone 60 per day a very high dose? I have symptoms of multiple sclerosis.pls tell me about the side effects of this dose.thnx

p.satyanarayana 2 years ago

satyanarayana psoriasis arthrities patient suffering since 20 years, and i am using whysolon 5mg per day with altraceta. i am facing heavy weight problem pls tell what can i do.

Raj 23 months ago

My daughter is suffered from SLE since 3 and half years. Now she is alright. But doctors has suggested tabs Wysolone, HCQs, shelcall, levipill,envas and cellcept. She is taking all the tabs daily. Is it any side effects. How can i control the tablets . Please suggest any doctors, please. Now she is O K. although doctors suggested. pl give suggestion sir...

amit singh 22 months ago

My mother taking wysolone since 5 years and now she is suffering from multi disorder s like pain in lims skin allergic stomach pain and other problems now plz advice me how I can reduce side effect of it my mail id singha1059@rediffmail .com

Vnagasarita07 21 months ago

Sir my son aged 3 yrs complete he suffered albinum +++ for the first urine test report doctor suggest wyslone 10 mg thrice a day for 6 weeks after complete 6 weeks the dose will be reduce 25 mg for day after day already weight gain and cheeks will grow but how to control this pls advice sir but next test the report will come nil

Kalyani 21 months ago

Sir for my huband docter gave wysolone 5 for the infertility problem

saravanan 20 months ago

I was affected by alopecia for 10 year My doctor advised to take wysolone 20 is advisable to take wat will cause if take that tablet

ganesh 19 months ago

My wife got aplastic anemia docter give her medicine. Wysolone 10. Alternet days is it right or wrong.

Jayanthi 19 months ago


My age 30, My doctor has suggested Wysolone 5 mg for hormone issues.. i have been taking this tablet since 6 months. i gain 7 kg wgt in 6 months, my cheeks become chubby and abdomen bloated, even though i am doing physical exercise reqularlyand iam going for checkup regularly and taking blood test. My doctor told that have to take this wysolone lifelong. I felt very bad due to chubby cheeks and wgt gain. So can you please suggest me how can i reduce my weight and also tell me is there any side effects, if i continue this up to end of my life.

Mahek Bajaj 18 months ago

I m taking Wysolone 20mg since last 20 days to cure skin ellergy as prescribed. I feel very weak n sleepy all d time n headache also. I m very afraid of its side effects as doctor has suggested to continue this tab 10mg for alternate day n after that also continue for some days.plz suggest it will be ok or something else .....

Srinivas goud 18 months ago

Sir I am suffering from skin allergie from 5 years it was very itching and pain full. From2 years before I consulted a skin specialist he told me to use wysolene 5mg for 15days. But I continued it for last month. I stopped it because of I had suffered from acidic problem. There is any alternative for wysolene 5mg. To get a relief from my skin problem. or can continue these tables. Please slove my problem.

Nagaraj 18 months ago

It is very informaive

Gunn Hinduja 17 months ago

I have rheumatoid athritis since 2006. Have one three and half year old son. Want to go for second pregnancy. Currently on methotrexate 5mg twice /sat and sun

saaz 1gm twice a day

VINEETA GAUTAM 16 months ago

dear sir,

i have infected by ammonia solution fumes due to high volatile and temperature is nearly 48 degree. doctor suggest me wysolon 10 mg.

i m feeling weakness too much..what should i take the precaution.plz suggest me ..thank u

D Prasad 15 months ago

thanks for invaluable information

Geetha suresh 14 months ago

Excellent inf. Pl.suggest alternate for wysolone

shashikala 14 months ago

my sister is suffering with rhumatoid artherities and she is using wysolone 5/10mg per day simultaneously homeo medicine. if she cannot use wysolone her pains increases and now she is becoming fat with cheeks. she with her body weight unable to walk freely and getting waist pain. Please suggest any alternate for wysolone else suggest what to take for reducing body weight. also please explain through email the side effects with this wysolone and effect of wysolone. how long to use or whenever to use.

dinishitha 13 months ago

I am 10 years old i use wysolone i started 20 mg redused 2.5 mg for every 15 days after i stop the wysolone when will I redus my weight for how many days

deepa 11 months ago

i using wysolone for my eye vision(floating dots visibility). doctor says that i have some infection in lungs. i taking tablets from 3 months and i put on weight 5 kgs within 3 months

major rao 7 months ago

using too much Wysolone 11type of side effect will effected but it can reduce by Ayurveda blood purifier tonic

like purodil ,and vatika kasai so many

Srikanth Sankaran 6 months ago

I am going to take this wysolone 10mg after consulting my physician Rheumatalogist whose suggestion is valuable for me.So before taking any steroid medications everyone must consult their physicians first.

viji 6 months ago

Hi, i had taken wysolone for 2 years, before 10 years. First i took 15mg then it was reduced to 10 mg after 6 months and then to 5mg after 1 year. But till now i was not able to reduce my body weight. What can i do for that ?

manoj kumar 5 months ago

I am suffering from polyarthopathy (diagnosed by apollo chennai) since 15 years. I have taken wysolone till 2012. Now again in 2016 i am experiencing same pain problems, i don't want to take wysolone because of its side effects. suggest me some other treatement /medicine for the same. Age 39 years , sex-male 5 months ago

My son is suffered from SLE since 3 and half years. Now she is alright. But doctors has suggested tabs Wysolone, HCQs, shelcall, levipill,envas and cellcept. She is taking all the tabs daily. Is it any side effects. How can i control the tablets . Please suggest any doctors, please. Now she is O K. although doctors suggested. pl give suggestion sir..

sachin sohal 5 months ago

My mother is a A.N.A positive patient . last one year and regular dose wysolone, per day 30 mg.8 weeks, at present 20 mg. continue but swelling in body . For this reason, there is mobility problems and tasteless problems . please suggest this problem solution give me

sans 4 months ago

Any allopathic medicine on chronic illness/disease functions as suppressant. In case of RA too, they prescribe immune-suppressant which supresses the immune. Remember the definition of allopathy for RA is auto-immune disease which means the immune system of our body reverses its role to attack us, thus suppress it.

I am undergoind Rheumatoid Arthristis (RA) treatment for last 9 years and have been taking allaopathy. Occassionally, I like to experiment with Ayurveda which I have learnt is about prevention and not cure. Ayurveda is not about taking pills and feeling good. It is about entire lifestyle. Pranayam and Yoga is major part of Ayurveda and should be practised very hard. Pranayam for 1.5 hrs morning and evening each will ensure control to the extent that you can do every work. I have experienced this situation after doing 3 months of pranayama for a long period.

Meghal shah vora 4 months ago

My mom is on wysolene 10 mg since 3 yrs.

she is already 82. But often she is suffering from several infections like infection in urine,

Stomach infections etc n she has become very weak. Please suggest some remedies for these infections. She is taking wysolene for temporal artherites.

manoj kumar Arya 3 months ago

my wife is suffering from fever from july 2015. Doctors diagnosed her for sacoidosis and preferred fpr 20 mg wysolone. Is it proper.

mdmary 3 months ago

Plz...Dont take wyslone. Its a Dangerus Medicine...It Kills. Choose Alternative.

meerasait. 3 months ago

My wife 33 years old.she had problem

Low platelate cell.she taken daily wysolon

5mg six months.what sideeffect this.please advise me?what solution for this ?what food eat ?please advise me.

Thank you.

Rajat 3 months ago

Plz keep faith in doctors.. I think every medicine have some side effects.. don't worry!

Ananya Bhakat 2 months ago

I am ananya bhakat. Before 2 months i suffered from jaundice (hepatice -e). that tine my doctor suggests me to used wysolon 10..Right now i am OK, but my cheeks become is not looking good..plz suggest mr what to do in that mail

sravan 2 months ago

Don't use wysolone

anand 8 weeks ago

i am taking wysolone from past 2 months ...i am nt getting slp

anitha 2 weeks ago

everone has asked question but not answer for any one.

i have SLE, and rheumatoid arthritis and i am taking medicine for last ten years wysolone, HCQS, Sazo 1000mg, Folvit and methotrexate(methotrexate weekly once) i am taking medicine i maintain weight but last two months i have put on weight i dont know the reasons but all my blood reports are normal. i think i have to chose the correct diet, doctors says we can take regular food but if they give us some clear food chart i think it will be very much useful.

Aliya khanum 5 days ago

i have a rheumatoid arthritis and im taking medicine for last 1month my age 16 i hve sooo much fever n fingers pain n knee full pain eyes feelings n face selling n body heating vry much how to going thiss prblm plzzzz gve the solution

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